Studies in detoxication. 69. The metabolism of alkylbenzenes: n-propylbenzene and n-butylbenzene with further observations on ethylbenzene*
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Studies in detoxication. 69. The metabolism of alkylbenzenes: n-propylbenzene and n-butylbenzene with further observations on ethylbenzene.
An account of our studies on the metabolic fate of toluene, ethyl-, i8opropyland tert.-butyl-benzenes has been given in earlier papers (Smith, Smithies & Williams, 1954a, b, c; Robinson, Smith & Williams, 1955; Robinson & Williams, 1955). The present paper deals with n-propyland n-butyl-benzenes. These two compounds were previously studied by Thierfelder & Klenk (1924), who showed that npropylb...
متن کاملFungal Metabolism of n-Alkylbenzenes.
Isolates of Paecilomyces, Verticillium, Beauveria, and Penicillium species were tested for ability to metabolize a variety of n-alkylbenzenes. Minimum side chain lengths were required for metabolism of these substrates. These were C(4) for the Paecilomyces sp., C(8) for the Verticillium sp., and C(9) for the other two isolates. Growth on dodecylbenzene yielded benzoic and phenylacetic acids as ...
متن کاملStudies in detoxication. 63. The metabolism of halogenobenzenes; (a) meta-dichlorobenzene (b) further observations on the metabolism of chlorobenzene.
2. o-Dichlorobenzene also gives rise to 3:4dichlorophenylmercapturic acid as a minor metabolite (5% of the dose). 3. p-Dichlorobenzene (0.5 g./kg.) is mainly oxidized to 2:5-dichlorophenol which is excreted conjugated. 2:5-Dichloroquinol is also formed (about 6% of the dose) but in contrast with o-dichlorobenzene no mercapturic acid or dichlorocatechol is formed. 4. The excretion ofthe metaboli...
متن کاملStudies in detoxication. 60. The metabolism of alkylbenzenes: isopropylbenzene (cumene) and derivatives of hydratropic acid.
isoPropylbenzene (cumene) is used as a solvent for cellulose lacquer, although not extensively. It has narcotic properties but no toxic effects in man have been reported (see Browning, 1953). When fed to rabbits it causes the excretion of considerable amounts of conjugated glucuronic acid and the urine reduces Benedict's reagent (Smith, Smithies & Williams, 1954a), but nothing definite is known...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1956
ISSN: 0306-3283
DOI: 10.1042/bj0640050